PRR has been shown to play a pivotal role in mediating the pathological effects induced by Ang II (Wang et al., 2014), protein load (Fang et al., 2018), advanced oxidation protein products (AOPPs) (Fang et al., 2023), and DOX-induced renal disease (Luo et al., 2020). The gene discussed is ATP6AP2; the disease is kidney disorder.