For example, clonidine and rilmenidine (inducing autophagy through the reduction in cAMP levels) are approved for the clinical treatment of hypertension (Leidal et al., 2018); rapamycin (inducing autophagy through mTOR inhibition) exerted anti-hypertrophic and anti-inflammatory efficiency in the aged heart in an animal study (Flynn et al., 2013). The gene discussed is MTOR; the disease is hypertensive disorder.