This may impact the development and progression of AD pathology itself, as tau and amyloid can be released by activity and/or exert their effects across synapses (Kamenetz et al., 2003; Cirrito et al., 2005; De Calignon et al., 2012; Liu et al., 2012; Khan et al., 2014; Wu et al., 2016). The gene discussed is MAPT; the disease is Alzheimer disease.