In rodent models of AD featuring amyloid or both amyloid and tau, evidence is inconsistent that CR INs degenerate in various hippocampal subregions (Baglietto-Vargas et al., 2010; Takahashi et al., 2010; Loreth et al., 2012; Aguado-Llera et al., 2018; Zallo et al., 2018; Giesers and Wirths, 2020; Shi et al., 2020; Li et al., 2022). The gene discussed is MAPT; the disease is Alzheimer disease.