In rodent AD models, PV INs can develop tau pathology (Soler et al., 2017; Siddhartha et al., 2018), and are found to degenerate, with loss in CA1 observed most consistently (Takahashi et al., 2010; Loreth et al., 2012; Silva Albequerque et al., 2015; Verdaguer et al., 2015; Huh et al., 2016; Mahar et al., 2016; Cattaud et al., 2018; Zallo et al., 2018; Giesers and Wirths, 2020; Seo et al., 2021; Li et al., 2022). The gene discussed is MAPT; the disease is Alzheimer disease.