ARID1A and malignant colon neoplasm: Similarly, in HCT116 (colon cancer cell) and OVCA429 (CCOC) cells, two additional ARID1AWT lines, loss of ARID1A protein by ARID1A CRISPR knockout led to increased sensitivity to BRD4i-DDRi combinations (Fig. 2B–C) (P < 0.01, P < 0.001 respectively).