CCL2 and Alzheimer disease: In genotype stratification analysis, we observed the same direction effects of elevated blood MCP-1 for increasing AD risk in rs696468-CC (Z = 3.94, p = 8.1×10− 4) and UNC5C rs72659964-AT + TT (Z = 3.35, p = 8.0×10− 4) carriers in both cohorts (Table 3), while in other genotypes the associations were inconsistent or insignificant between the two cohorts.