One locus on chromosome 12 showed genome-wide significant interactions with MCP-1 on AD risk (p < 5.0×10− 8) (Table S1), including 18 SNPs in intronic region of gene NAV3 (rs696468 (MAF = 0.14) as sentinel SNP) as shown in Fig. 2B. This evidence concerns the gene CCL2 and Alzheimer disease.