Another significant SNP rs72659964 (p < 1.0×10− 7 in FHS and p < 5.0×10− 8 in meta-analysis) in UNC5C was also selected for further analyses since UNC5C is a homolog of NAV3 and is associated with familial and sporadic AD.(36–38) As shown in Table 2, the SNP main effect alone on AD risk was not significant (p > 0.05). This evidence concerns the gene NAV3 and Alzheimer disease.