CCL2 and Alzheimer disease: Elevated MCP-1 concentration (log-transformed and percentile cutoffs) was associated with a higher incidence of AD among UNC5C rs72659964-AT + TT carriers (HR = 80.74, 95% CI = 8.32, 783.28, p = 1.5×10− 4), but this increasing trend was largely attenuated for the UNC5C rs72659964-AA carriers (Table S2 and Fig. 3B).