BMP2 and neoplasm: Although the usefulness of BMP-2 for bone induction has not been questioned, the exponential rise in the clinical use of BMP-2 (InfuseTM Bone Graft, Medtronic) use has been described to be associated with serious side effects 6, such as inflammatory complications that may cause significant swelling and compromise a patient’s airway, cause ectopic bone, and tumor-like formation 7.