Additionally, mutations in the genes encoding most other BAF subunits also cause similar features, leading to the suggestion that a defective BAF complex drives a broad neurodevelopmental spectrum with autistic features at the mild end, classic Coffin-Siris syndrome in the middle, and Nicolaides-Baraitser syndrome representing the most severe disease (3). The gene discussed is BANF1; the disease is intellectual disability-sparse hair-brachydactyly syndrome.