Given that a clinical continuum is observed in Coffin-Siris and Nicolaides-Baraitser syndromes depending on which BAF encoding gene is mutated (3, 53), it is not unusual to consider that SMARCA1, SMARCA5, and BPTF NDDs may also align along a clinical spectrum. Here, SMARCA1 is linked to intellectual disability - sparse hair - brachydactyly.