Given that a clinical continuum is observed in Coffin-Siris and Nicolaides-Baraitser syndromes depending on which BAF encoding gene is mutated (3, 53), it is not unusual to consider that SMARCA1, SMARCA5, and BPTF NDDs may also align along a clinical spectrum. The gene discussed is SMARCA5; the disease is intellectual disability-sparse hair-brachydactyly syndrome.