The shared loci between AD and immune-mediated diseases implicated several genes, including <i>GRAMD1B, FUT2, ADAMTS4, HBEGF, WNT3, TSPAN14, DHODH, ABCB9</i> and <i>TNIP1</i>, all of which are protein-coding genes and thus potential drug targets. The gene discussed is ADAMTS4; the disease is Alzheimer disease.