NFE2L2 and cancer: According to the studies, the Notch signalling pathway, which plays a role in the growth and differentiation of cells, increases the expression of Nrf2 and its downstream genes, and on the other hand, Nrf2 regulates the Notch signalling pathway, so disruption in each of the Notch pathways and Nrf2 has been linked to many diseases and cancers, including BC (111, 112).