TRPV4 (transient receptor potential cation channel subfamily V member 4) and Piezo114 are ion channels that respond to a wide variety of mechanical stimuli, such as shear stress,15 membrane stretch,16 or pressure,17 and may also be involved in vascular or immune aspects of advanced CLD, as they play such roles in other systems.18 Here, TRPV4 is linked to congenital secretory chloride diarrhea 1.