Statins are known to improve endothelial dysfunction through a variety of mechanisms, among them Rho-GTPase-driven ones107 and their benefits in CLD have been abundantly demonstrated.[108], [109], [110] At the cellular level, simvastatin has been shown to improve matrix stiffness-induced endothelial dysfunction mediated by Rho activity.111. Here, RHO is linked to endothelial dysfunction.