While gene expression of inflammatory markers Ccl5 and Tnfα remained unchanged among the groups (Fig. S3), hepatic hydroxyproline content as well as PSR (as a marker of hepatic fibrosis)-positive areas were reduced in liver sections of cilofexor-treated Mdr2-/- mice in comparison to Mdr2-/- control animals (Fig. 1C and D). This evidence concerns the gene ABCB4 and Hepatic fibrosis.