The tumor-bearing Adra2ac−/− mice responded positively to αGC injection, exhibiting a significant increase in systemic IFN-γ and control of tumor growth without any significant alteration in the systemic levels of hepatic enzymes, thus corroborating the hepatoprotective effect of adrenergic signaling (Figures 4A–4D). The gene discussed is IFNG; the disease is neoplasm.