The top 15 metabolic pathways of KSDMs are central carbon metabolism in cancer, glucagon signaling pathway, carbon metabolism, citrate cycle (TCA cycle), alcoholism, prolactin signaling pathway, taste transduction, parkinson disease, pentose phosphate pathway, glyoxylate and dicarboxylate metabolism, ABC transporters, biosynthesis of amino acids, galactose metabolism, alanine, aspartate and glutamate metabolism, pathways in cancer (Figure 4). The gene discussed is PRL; the disease is alcohol dependence.