PITX1 and acute leukemia: While in most studies, PITX1 has been widely reported as a tumor suppressor gene, some researchers believe that PITX1 is an oncogenic gene that promotes the development and progression of tumors, such as the role of PITX1 in KRAS-mutant colorectal cancer cells and acute leukemia (43, 118, 123), here we summarize some of the target proteins of PITX1 and the corresponding functions (Table 2).