On the one hand PITX1’s interactions with key genes such as P53 and RASAL1 have been shown to impede tumor proliferation, on the other hand, PITX1 has also been implicated in collaborative efforts to drive tumor progression and foster the formation of tumor stem cells in conjunction with SOX2, suggesting that the full extent of PITX1’s role remains veiled. Here, SOX2 is linked to neoplasm.