In hepatocellular carcinoma (HCC), miR-186-5p interacted with long non-coding RNA 665 (LINC00665) and circular RNA protein kinase C iota (circ-PRKCI) to inhibit cellular viability and tumor progression by regulating Forkhead Box K1 (FOXK1) expression. Here, PRKCI is linked to hepatocellular carcinoma.