The screened wavelet features are mainly based on glcm and first-order statistics, glcm reflects the spatial relationship between pixels and determines the frequency of occurrence of a particular combination of pixels in the image, first-order statistical features mainly describe distribution of pixel or voxel intensities within the tumor region of the image, and Skewness represents the degree of asymmetry of imaging in histogram distribution, which reflects the fact that grayscales of the GPC3-positive HCC are more asymmetric, inhomogeneous, and heterogeneous than those of the negative ones. The gene discussed is GPC3; the disease is neoplasm.