A recent study compared insulin-fasting levels and the homeostatic model assessment (HOMA) index between hypothyroid children with obesity and those with normal weight, with the addition of a healthy control group; the results showed higher leptin and insulin-fasting levels and a higher HOMA index in both hypothyroid children with obesity and normal weight, with higher values in the population with obesity compared to healthy controls. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.