Recent research has highlighted the significant potential of endothelial cell (EC)-derived exosomal Profilin 2 (PFN2) as a valuable target in the repair of MI injury via angiogenesis, which promotes EC proliferation, migration, and tube formation through the PI3K-PFN2-ERK axis (Li, Z., et al., 2022). The gene discussed is PFN2; the disease is myocardial infarction.