CRP and Sepsis: NICE guidance also recognised that CRP is very likely to be monitored in the NHS during sepsis care, but there is a paucity of prospectively tested CRP-based algorithms and interventional data regarding efficacy and safety for guiding antibiotic duration.10 Therefore, the ADAPT-Sepsis trial has been designed to respond to these evidence gaps identified by NICE and has been funded by NIHR HTA following a specific commissioning brief call (15/99).