CLIC3 and schizophrenia: It should also be noted that the antipsychotic drug - risperidone also eliminated the inhibitory effects of MK-801 on CLIC3 expression in both PFC and CPu (both p < 0.05 vs. the MK-801 group) (Figures 8A,B), indicating that CLIC3 might be a potential therapeutic target of schizophrenia.