Immunodominant proteins such as EBNA2, 3A, 3B, 3C, and -LP are absent, redirecting immune attention towards remaining target antigens, such as EBNA1 in BL, EBNA1, LMP1, and LMP2 in HL, and primarily EBNA1 and LMP2 in NPC, GCa, ENKTL, and DLBCL. Here, PSMB9 is linked to diffuse large B-cell lymphoma.