Except for the previously mentioned HLA-DRB1*03:01, this group of alleles includes HLA-B*08:01, B*39:06, B*37:01, C*07:01, C*14:02, C*03:02, C*17:01, DRB1*11:01, DRB1*13:03, DRB1*01:03, DRB1*14:01, DQB1*03:01, DQB1*02:01. On the other hand, alleles HLA-C*04:01, C*03:04, C*07:02 and DRB1*15:02 were significantly less frequent in GO patients as compared to GD without GO or controls (15). This evidence concerns the gene HLA-C and geroderma osteodysplastica.