OSM and familial pancreatic carcinoma: Treatment of multiple human pancreatic cancer cell lines with recombinant human OSM (rhOSM) induced EMT via reduction of E-cadherin and induction of ZEB1 as well as upregulation of OSMRβ, leading to a positive feedback loop of increased OSM-mediated STAT3 signaling that maintains the malignant phenotype of these cells (162).