CXCL10 and ICAM-1 expression were both suppressed when inhibitors of NF-κB and STAT3 were introduced, indicating that OSM-mediates STAT3 signaling and IL-1β-mediated NF-κB signaling may promote infiltration and retention of Th1 cells, leading to periodontal disease (62). The gene discussed is STAT3; the disease is periodontal disorder.