In contrast with the observations made regarding CD3+ T cell infiltration, CD8+ T cell infiltration was significantly higher in mice with complete Id1 depletion (tumor cells plus tumor microenvironment) (p > 0.0001; IDKO LLC_Sc/sh-ID1 p = 0.0497) (Figures 3A, B; Supplementary Figure S2B; Table 2). This evidence concerns the gene ID1 and neoplasm.