In our study, after co-culture of CD8+ T cells from patients with DLBCL and SU-DHL6/OCI-LY3 cells in vitro, addition of LAG-3 and/or PD-1 inhibitors alone partially restored the function of CD8+ T cells, resulting in increased perforin and granzyme B secretion and an elevated proportion of tumor cells undergoing apoptosis. The gene discussed is CD8A; the disease is diffuse large B-cell lymphoma.