Comparing relapsing with non-relapsing patients, GPA-PR3-ANCA patients exhibited a higher degree of ΔIgG1 bisection at diagnosis, while MPA-MPO-ANCA patients showed a trend towards a lower degree of ΔIgG1 bisection if they would relapse (Figures 2, S6). The gene discussed is PRTN3; the disease is microscopic polyangiitis.