ID93 showed immunogenicity in a variety of animal models (mice, guinea pigs, rhesus monkeys) and induced a multifunctional CD4+ Th1 cell response characterized by IFN-γ, TNF-α, and IL-2, which reduced the number of bacteria in the lungs of drug-resistant Mtb strains that attacked the lungs of the animals, and effectively lowered the mortality rate of tuberculosis in experimental animals (118). The gene discussed is CD4; the disease is tuberculosis.