MRC1 and necrotizing enterocolitis: However, antibiotic treatment in early life can lead to gut microbial disorders, affect Mφ differentiation and Wnt secretion, lead to proliferation defects of MNCs, and promote the pathogenesis of NEC, while Lactobacillus treatment or supplementation with exogenous CD206+ M2 macrophages can partially rescue Paneth cell differentiation deficiency and NEC-like phenotype (78).