NECTIN2 and secondary progressive multiple sclerosis: PVRL2 positivity was associated with increased risk of SPMS [OR 12.25, bootstrapped 95% CI: (1.15, 23.10), P = 0.031] (Figure 1) with 93.3% sensitivity (14/15 SPMS patients), and 94.4% negative predictive value (17/18 negative genetic tests).