A majority of chronic urticaria cases are chronic spontaneous urticaria (CSU), with two distinctive subtypes being recognised: autoallergic CSU (type 1 autoimmunity) with IgE auto-antibody involvement and autoimmune CSU (type IIb autoimmunity) with IgG auto-antibody involvement (4, 5). The gene discussed is IGHE; the disease is Autoimmunity.