PARP1 and renal cell carcinoma: As a tumor suppressor gene, TRAF3IP2 antisense RNA1 (TRAF3IP2-AS1) binds to poly ADP-ribose polymerase (PARP1) mRNA directly, boosting the m6A modification of PARP1 mRNA, attenuating PARP1 mRNA, and improving PTEN expression via binding miR-200a-3p, miR-153-3p, and miR-141–3p, therefore greatly decreasing PARP1 expression and suppressing NONO - TFE3 translocated RCC.