(1) Different degrees of myalgia/myasthenia/myositis (with or without elevated CK levels); (2) Creatine kinase >10 times of the upper limit of normal value; (3) Abnormal urine examination (dark brown, myoglobin urine); (4) With or without renal function damage oliguria or serum creatine at least increase 0.5 mg/dL (44 μmol/L) (no primary muscle disease, rhabdomyolysis if the conditions are met; if not fully satisfied, associated myopathy) (31). This evidence concerns the gene MB and Fatigable weakness.