Furthermore, MPTP treatment induced a pronounced reduction in climbing rates, the emergence of offspring, cell viability, AChE, catalase, and glutathione-S-transferase activity, eosinophilia, rarefaction of CNS white matter, segmental loss of CNS neurons, and increased H2O2 and NO levels compared to the control group. Here, HPGDS is linked to Increased total eosinophil count.