A similar study testing NRF2 loss in a combined model of amyloidopathy and tauopathy (AT mice) demonstrated that AT-Nrf2−/− mice exhibited increased levels of phosphorylated tau, higher levels of Aβ aggregates, and more severe learning and memory deficits than their AT-Nrf2+/+ counterparts (Rojo et al., 2017). The gene discussed is NFE2L2; the disease is tauopathy.