NFE2L2 and Huntington disease: SF, curcumin, and tert-butylhydroquinone (tBHQ) were also shown to protect against 3-NP-induced HD in an NRF2-dependent manner (Sandhir et al., 2014; Jang and Cho, 2016; Silva-Palacios et al., 2017), and a novel covalent modifier MIND4, and its derivative 4–17, activated NRF2 and suppressed oxidative stress in HD cell and animal models, as well as patient monocytes (Quinti et al., 2016; Quinti et al., 2017).