Much like the MPTP-induced model of PD, the cell type-relevance of NRF2 may also be important to consider, as astrocyte-specific overexpression of NRF2 increased survival of mice overexpressing mutant superoxide dismutase 1 (SOD1G39A), an established model of ALS (Vargas et al., 2008). This evidence concerns the gene NFE2L2 and Parkinson disease.