In summary, to our knowledge, this is the first study that investigated the effect of MYBL2/UBE2C regulatory axis on GC and found that MYBL2 could inhibit DNA damage and promote cell viability and DDP resistance in GC cells by activating UBE2C, which indicated that MYBL2/UBE2C axis was closely related to GC. This evidence concerns the gene MYBL2 and gastric cancer.