Activation of the NF-κB pathway promotes the excessive release of pro-inflammatory factors (TNF-α, IL-6, IL-1β, and so on) but inhibits the secretion of anti-inflammatory factors (interleukin 10); the imbalance between pro-inflammatory and anti-inflammatory factors will result in ALI (Han et al., 2019). The gene discussed is IL1B; the disease is acute respiratory distress syndrome.