Lactobacillus, which is particularly abundant in obese mice, can regulate body weight by hydrolyzing indigestible polysaccharides into easily absorbed monosaccharides, thereby activating lipoprotein lipase, and it regulates DNA methylation levels at the host miR-378a promoter by increasing acetate and butyrate in SCFAs, thereby preventing the development of obesity and glucose intolerance (Du et al., 2021). The gene discussed is LPL; the disease is obesity disorder.