HIF1A and neoplasm: In addition, the hypoxic BM niche induces the stabilization of hypoxia‐inducible factor 1‐alpha (HIF‐1α) in hematopoietic stem cells (HSCs),60 which increases the production of angiogenic factors and angiogenesis to increase oxygen delivery to tumor cells, and thereby stimulates tumor growth.61, 62, 63