Furthermore, we compared the concentration of seven kinds of lipids in the plasma of women in early gestation among the control and different clusters of CHDs and found that the level of free fatty acids was significantly downregulated in the CHD group, while the other six lipids, including low‐density lipoprotein (LDL), triglyceride, high‐density lipoprotein, total cholesterol (TC), apolipoprotein A (APOA), and apolipoprotein B (APOB), were upregulated in the CHD group (Fig 4E). The gene discussed is APOB; the disease is coronary artery disorder.