PTH1R pathogenic variants are found in 72% of primary failure of tooth eruption (PFE) cases with five clinical and radiographic phenotypes: involvement of posterior teeth, involvement of the distal teeth to the most affected mesial teeth, supraclavicular manifestations, altered vertical growth of the alveolar process and posterior open bite (Grippaudo et al., 2021). The gene discussed is PTH1R; the disease is primary failure of tooth eruption.