Hence, Lamin C gene replacement is suitable for the treatment of LMNA DCM with haploinsufficiency mechanism through compensation for the loss of functional Lamin A/C in which the majority of mutations affect both Lamin A and C. On the other hand, the rescue role of Sun1 knockdown, KASH overexpression or DNSUN1 overexpression will extend to LMNA DCM caused by dominant negative mutations. Here, SUN1 is linked to familial dilated cardiomyopathy.