Among them, Smad3 shRNA, Yy1, combination of Bmp7 and Ctgf shRNA (Bmp7-Ctgf shRNA), aYAP1, Sun1 shRNA, Lamin A, and Lamin C, can significantly improve the ejection fraction (EF) in Lmna DCM. Here, SUN1 is linked to familial dilated cardiomyopathy.