However, knockdown of Mapk14 (coding for p38α), Raptor (a key component for mTORC1 signaling) or overexpression of Fgf16 (a downstream gene of Gata4) specifically in CMs did not significantly suppress Lmna DCM, suggesting their protective roles might be contributed by non-CMs or are specific to certain disease models [46]. Here, RPTOR is linked to familial dilated cardiomyopathy.