LMNA and familial dilated cardiomyopathy: Hence, Lamin C gene replacement is suitable for the treatment of LMNA DCM with haploinsufficiency mechanism through compensation for the loss of functional Lamin A/C in which the majority of mutations affect both Lamin A and C. On the other hand, the rescue role of Sun1 knockdown, KASH overexpression or DNSUN1 overexpression will extend to LMNA DCM caused by dominant negative mutations.