PKM and neoplasm: Consistently, tumor size and weight, and expression of FTO, GLUT1, PKM2 and Ki67 increased in Lv-oeFTO-IT1 group compared to Lv-ctrl group, while co-transfection with Lv-siFTO reversed the tumor size and weight, and expression of FTO, GLUT1, PKM2 and Ki67 facilitated by overexpression of FTO-IT1 (Supplementary Fig. S10A-D).