umor Necrosis Factor (TNF), a pivotal pro-inflammatory cytokine in the pathogenesis of RA, has been found to inhibit ferroptosis by upregulating SLC7A11, glutamate-cysteine ligase catalytic subunit (GCLM), and glutamate-cysteine ligase regulatory subunit (GCLC). The gene discussed is GCLC; the disease is rheumatoid arthritis.