A significant increase in promoter methylation of LGALS2 was observed in tumor samples as compared to the normal group (P < 0.0001) (Fig. 8A), and this was also significantly associated with the tumor type and patient age (Fig. 8B,C), which were inversely correlated with LGALS2 mRNA expression level (Fig. 1B). Here, LGALS2 is linked to neoplasm.