Nakamura et al. demonstrated a variation in tumor anatomical location, indicating IDH, EPHA2 and BAP1 mutations and FGFR2 fusions in iCCA, whereas extrahepatic tumors preferentially show PRKACA and PRKACB fusions as well as mutations in ELF3 and ARID1B. This evidence concerns the gene EPHA2 and neoplasm.