APBB1 and Alzheimer disease: While modulation of APP processing cannot explain the beneficial effect of quercetin or Abl inhibition in C. elegans AD models, some of the enzymes involved in APP processing in mammals are conserved in nematode (e.g., Fe65/feh-1, neprilysin/nep-1 [3, 82, 83]) and, if affected by the two interventions, may still impact on Aβ degradation or toxicity.