Nonetheless, considering that C. elegans APP related protein (APL-1) does not contain an Aβ sequence and the available C. elegans AD models rely on transgenic expression of the human Aβ toxic peptide [3, 14], the common beneficial effects of quercetin in cells and C. elegans must involve Abl-regulated pathways impacting on Aβ levels and/or toxicity (rather than on APP processing). Here, ADI1 is linked to Alzheimer disease.