Pachymaran can lead to the imbalance of (B-cell lymphoma-2 (Bcl-2)/Bcl2-associated X (Bax) by regulating the ratio of Bcl-2/Bax protein, inhibits the growth of tumor cells and induces apoptosis of human breast cancer cells by activating apoptosis signaling pathway14,15. This evidence concerns the gene BCL2 and breast cancer.