The induction of expression of pro-death BH3 domain family members BAX and BBC3 suggested that MDM2 inhibition may prime T-ALL cells for induction of apoptosis after treatment with inhibitors of pro-survival BH3 domain proteins, such as venetoclax (targeting Bcl-2) or navitoclax (targeting Bcl-2 and Bcl-xL). This evidence concerns the gene MDM2 and acute lymphoblastic leukemia.