We found a positive association of OPG rs2073618 gene polymorphism (1181G > C) in diabetes patients with hypertension as there was a significant over-representation of polymorphic GG genotype in patients when compared with healthy control (OR: 2.79; p = 0.0014; Table 4), and patients with diabetes mellitus without hypertension (T2D + HTN) (OR: 3.004; p = 0.0006; 5). Here, TNFRSF11B is linked to type 2 diabetes mellitus.