We hypothesize that any alteration in the levels of receptors such as RANK and OPG; their major ligands such as RANKL and TNF-alpha; or the corresponding allele polymorphism of OPG could play a pivotal role in insulin resistance associated hypertension and subsequent increase in CV risks in the Southern Indian (Tamil) population. The gene discussed is TNFRSF11B; the disease is hypertensive disorder.