The remaining biomarkers: ALT (4 studies, 1586 participants)26,34,42,48, alkaline phosphatase (ALP, 2 studies, 347 participants)34,48, and CPK (2 studies and 1347 participants)34,42 were not associated with a higher risk of severe dengue (p > 0.05). Here, PIK3C2A is linked to dengue disease.